Major area employers include:
- E.M. Kauffman Foundation
- Blue Cross/Blue Shield
- Midwest Research Foundation
- Cleveland Chiropractic College
- Nazarene World Headquarters and Seminary
- Health Midwest
(Research Medical Center and Baptist Medical Center)
- H & R Block
- Rockhurst College
- Stowers Institute
- Swope Parkway Health Center
- University Of Missouri of Kansas City
21% of the land area in Southtown is devoted to commercial and institutional uses which support an employment base of over 20,000 jobs.
20 office buildings with total space of over 1,000,000 sq. ft. with a vacancy rate of 11%. Rental rates range from $6/sq. ft. and up.